SYRE · Nasdaq · CIK 0001636282

Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.’s most recent SEC filing in our snapshot is a Form SCHEDULE 13D/A filed on Oct 9, 2026. In fiscal 2025 (year ended Dec 31, 2025) it reported revenue of $0 and net income of -$155.2M, according to its XBRL data on EDGAR. Its EDGAR record lists 42 Form 4 insider filings from the 12 months before our last refresh.

SEC EDGAR snapshot updated Oct 27, 2026, 11:27 PM EDT. See all filings on sec.gov.

Revenue, FY2025
$0
Net income, FY2025
-$155.2M
Form 4 filings on record, past 12 months
42

Company overview

Legal name (as filed)
Spyre Therapeutics, Inc.
Ticker
SYRE
SEC Central Index Key (CIK)
0001636282
Industry (SIC)
Pharmaceutical Preparations (code 2834)
Business address
WALTHAM, MA
State or country of incorporation
DE
Fiscal year ends
December 31
SEC filer category
Large accelerated filer
Position in SEC ticker list
#991 of the 3,000 companies we track

Five-year financial highlights

Full-year figures from Spyre Therapeutics, Inc.’s annual reports, as tagged in XBRL and published by the SEC. Amounts are in U.S. dollars; the fiscal year is named for the calendar year in which it ends.

Revenue
$18.7MFY2021$2.3MFY2022$886.0KFY2023$0FY2024$0FY2025
Net income
-$65.8MFY2021-$83.8MFY2022-$338.8MFY2023-$208.0MFY2024-$155.2MFY2025
SYRE annual results
ItemFY2021
ended Dec 31, 2021		FY2022
ended Dec 31, 2022		FY2023
ended Dec 31, 2023		FY2024
ended Dec 31, 2024		FY2025
ended Dec 31, 2025
Revenue$18.7M$2.3M$886.0K$0$0
Net income-$65.8M-$83.8M-$338.8M-$208.0M-$155.2M
Diluted EPS-$25.02-$24.86$13.76——
Total assets$109.9M$71.1M$341.9M$608.5M$777.8M
Cash and equivalents$15.1M$34.9M$188.9M$89.4M$85.7M

XBRL tags used: revenue = RevenueFromContractWithCustomerExcludingAssessedTax; netIncome = NetIncomeLoss; assets = Assets; eps = EarningsPerShareDiluted; cash = CashAndCashEquivalentsAtCarryingValue. EPS is shown as originally reported for each year and may not be adjusted for later stock splits. A dash means the company did not report that item in a form we could match.

How to read these numbers

Revenue is the money a company brings in from selling its products and services; net income is what is left after all expenses, interest and taxes. Diluted EPS spreads net income across every share that could exist if options and convertible securities were exercised. Total assets and cash are balance-sheet figures measured on the last day of the fiscal year. For the full story — segment results, one-time charges, guidance — read Management’s Discussion and Analysis in the Form 10-K.

Latest key reports

The most recent filing of each major report type, even if it falls outside the 40 newest filings below.

SYRE latest annual, quarterly, current and proxy reports
FiledFormWhat it isOriginal
Feb 19, 202610-KAnnual report· period Dec 31, 2025Document · Index
Aug 4, 202610-QQuarterly report· period Jun 30, 2026Document · Index
Oct 7, 20268-KMaterial agreement· period Oct 5, 2026Document · Index
Apr 10, 2026DEF 14ADefinitive proxy statement· period May 27, 2026Document · Index

Recent SEC filings

The 40 newest documents filed by or about Spyre Therapeutics, Inc., by form type:

4 ×15144 ×118-K ×5SCHEDULE 13D/A ×2424B5 ×2SCHEDULE 13G/A ×2SCHEDULE 13G ×110-Q ×1S-3ASR ×1
SYRE recent filings
FiledFormWhat it isOriginal
Oct 9, 2026SCHEDULE 13D/AActive beneficial ownership report (over 5%)Document · Index
Oct 7, 20268-KMaterial agreement· period Oct 5, 2026Document · Index
Oct 6, 2026424B5424B5Document · Index
Oct 5, 2026424B5424B5Document · Index
Oct 2, 20264Statement of changes in beneficial ownership (insider trade)· period Oct 1, 2026Document · Index
Oct 2, 20264Statement of changes in beneficial ownership (insider trade)· period Oct 1, 2026Document · Index
Oct 2, 20264Statement of changes in beneficial ownership (insider trade)· period Sep 30, 2026Document · Index
Oct 1, 2026144Notice of proposed sale of securitiesDocument · Index
Oct 1, 2026144Notice of proposed sale of securitiesDocument · Index
Oct 1, 2026SCHEDULE 13GPassive beneficial ownership report (over 5%)Document · Index
Sep 30, 2026144Notice of proposed sale of securitiesDocument · Index
Sep 8, 20268-KRegulation FD disclosure; Other events· period Sep 8, 2026Document · Index
Sep 3, 20264Statement of changes in beneficial ownership (insider trade)· period Sep 1, 2026Document · Index
Sep 3, 20264Statement of changes in beneficial ownership (insider trade)· period Sep 1, 2026Document · Index
Sep 3, 20264Statement of changes in beneficial ownership (insider trade)· period Sep 1, 2026Document · Index
Sep 1, 2026144Notice of proposed sale of securitiesDocument · Index
Aug 25, 20268-KRegulation FD disclosure; Other events· period Aug 25, 2026Document · Index
Aug 14, 2026SCHEDULE 13G/APassive beneficial ownership report (over 5%)Document · Index
Aug 14, 2026SCHEDULE 13G/APassive beneficial ownership report (over 5%)Document · Index
Aug 10, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 7, 2026Document · Index
Aug 7, 2026144Notice of proposed sale of securitiesDocument · Index
Aug 7, 2026144Notice of proposed sale of securitiesDocument · Index
Aug 5, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 3, 2026Document · Index
Aug 5, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 3, 2026Document · Index
Aug 4, 20268-KResults of operations· period Aug 4, 2026Document · Index
Aug 4, 202610-QQuarterly report· period Jun 30, 2026Document · Index
Aug 3, 2026144Notice of proposed sale of securitiesDocument · Index
Jul 2, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 2, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 2, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 1, 2026144Notice of proposed sale of securitiesDocument · Index
Jun 26, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 25, 2026Document · Index
Jun 26, 2026S-3ASRSimplified registration statementDocument · Index
Jun 25, 2026144Notice of proposed sale of securitiesDocument · Index
Jun 23, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 22, 2026Document · Index
Jun 23, 2026144Notice of proposed sale of securitiesDocument · Index
Jun 23, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 23, 2026Document · Index
Jun 23, 2026SCHEDULE 13D/AActive beneficial ownership report (over 5%)Document · Index
Jun 22, 2026144Notice of proposed sale of securitiesDocument · Index
Jun 15, 20268-KRegulation FD disclosure; Other events· period Jun 15, 2026Document · Index

Insider filing activity

42 Form 4 filings appear in Spyre Therapeutics, Inc.’s EDGAR record between Oct 28, 2025 and our last refresh. Most are reports by the company’s own directors, officers and 10% owners, but EDGAR also lists a Form 4 under a company when the company itself is the insider — for example, when it owns more than 10% of another public company. Foreign private issuers’ own insiders generally do not file Form 4. A high count is not by itself a signal: many Form 4s report routine stock awards, tax withholding or sales under pre-arranged Rule 10b5-1 plans. Open each filing to see the transaction code, share count and price. What a Form 4 shows.

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Source

  • U.S. Securities and Exchange Commission, EDGAR submissions for CIK 0001636282 and XBRL company facts. Spyre Therapeutics, Inc. on EDGAR.
  • Snapshot updated Oct 27, 2026, 11:27 PM EDT. The SEC does not endorse OpenFilings. Company names and tickers are used only to identify the filer; no logos are shown.

Not investment advice. This page summarizes public SEC filings for information only. Figures may contain errors or omissions; confirm everything in the original filing before relying on it.