IONS · Nasdaq · CIK 0000874015

IONIS PHARMACEUTICALS INC

IONIS PHARMACEUTICALS INC’s most recent SEC filing in our snapshot is a Form 8-K filed on Oct 23, 2026. In fiscal 2025 (year ended Dec 31, 2025) it reported revenue of $943.7M and net income of -$381.4M, according to its XBRL data on EDGAR. Its EDGAR record lists 104 Form 4 insider filings from the 12 months before our last refresh.

SEC EDGAR snapshot updated Oct 27, 2026, 11:27 PM EDT. See all filings on sec.gov.

Revenue, FY2025
$943.7M
Net income, FY2025
-$381.4M
Form 4 filings on record, past 12 months
104

Company overview

Legal name (as filed)
IONIS PHARMACEUTICALS INC
Ticker
IONS
SEC Central Index Key (CIK)
0000874015
Industry (SIC)
Pharmaceutical Preparations (code 2834)
Business address
CARLSBAD, CA
State or country of incorporation
CA
Fiscal year ends
December 31
SEC filer category
Large accelerated filer
Position in SEC ticker list
#1083 of the 3,000 companies we track

Five-year financial highlights

Full-year figures from IONIS PHARMACEUTICALS INC’s annual reports, as tagged in XBRL and published by the SEC. Amounts are in U.S. dollars; the fiscal year is named for the calendar year in which it ends.

Revenue
$810.5MFY2021$587.4MFY2022$787.6MFY2023$705.1MFY2024$943.7MFY2025
Net income
-$28.6MFY2021-$269.7MFY2022-$366.3MFY2023-$453.9MFY2024-$381.4MFY2025
IONS annual results
ItemFY2021
ended Dec 31, 2021		FY2022
ended Dec 31, 2022		FY2023
ended Dec 31, 2023		FY2024
ended Dec 31, 2024		FY2025
ended Dec 31, 2025
Revenue$810.5M$587.4M$787.6M$705.1M$943.7M
Net income-$28.6M-$269.7M-$366.3M-$453.9M-$381.4M
Diluted EPS-$0.20-$1.90-$2.56-$3.04-$2.38
Total assets$2.6B$2.5B$3.0B$3.0B$3.5B
Cash and equivalents$869.2M$276.5M$399.3M$242.1M$372.3M

XBRL tags used: revenue = RevenueFromContractWithCustomerExcludingAssessedTax; netIncome = NetIncomeLoss; assets = Assets; eps = EarningsPerShareDiluted; cash = CashAndCashEquivalentsAtCarryingValue. EPS is shown as originally reported for each year and may not be adjusted for later stock splits. A dash means the company did not report that item in a form we could match.

How to read these numbers

Revenue is the money a company brings in from selling its products and services; net income is what is left after all expenses, interest and taxes. Diluted EPS spreads net income across every share that could exist if options and convertible securities were exercised. Total assets and cash are balance-sheet figures measured on the last day of the fiscal year. For the full story — segment results, one-time charges, guidance — read Management’s Discussion and Analysis in the Form 10-K.

Latest key reports

The most recent filing of each major report type, even if it falls outside the 40 newest filings below.

IONS latest annual, quarterly, current and proxy reports
FiledFormWhat it isOriginal
Feb 26, 202610-KIONIS PHARMACEUTICALS, INC. 10-K 12-31-2025· period Dec 31, 2025Document · Index
Jul 29, 202610-QIONIS PHARMACEUTICALS, INC. 10-Q 06-30-2026· period Jun 30, 2026Document · Index
Oct 23, 20268-KRegulation FD disclosure; Other events· period Oct 23, 2026Document · Index
Apr 23, 2026DEF 14ADefinitive proxy statement· period Jun 4, 2026Document · Index

Recent SEC filings

The 40 newest documents filed by or about IONIS PHARMACEUTICALS INC, by form type:

4 ×248-K ×8144 ×6S-8 ×110-Q ×1
IONS recent filings
FiledFormWhat it isOriginal
Oct 23, 20268-KRegulation FD disclosure; Other events· period Oct 23, 2026Document · Index
Oct 21, 20268-KRegulation FD disclosure; Other events· period Oct 20, 2026Document · Index
Oct 19, 20264Statement of changes in beneficial ownership (insider trade)· period Oct 15, 2026Document · Index
Oct 19, 20264Statement of changes in beneficial ownership (insider trade)· period Oct 15, 2026Document · Index
Oct 16, 2026144Notice of proposed sale of securitiesDocument · Index
Sep 23, 20268-KRegulation FD disclosure; Other events· period Sep 23, 2026Document · Index
Sep 4, 20268-KRegulation FD disclosure; Other events· period Sep 4, 2026Document · Index
Sep 4, 20268-KRegulation FD disclosure; Other events· period Sep 3, 2026Document · Index
Sep 2, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 31, 2026Document · Index
Sep 2, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 31, 2026Document · Index
Sep 2, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 31, 2026Document · Index
Sep 2, 20264Statement of changes in beneficial ownership (insider trade)· period Aug 31, 2026Document · Index
Jul 31, 2026S-8Registration of employee benefit plan securitiesDocument · Index
Jul 31, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 30, 2026Document · Index
Jul 29, 20268-KResults of operations· period Jul 29, 2026Document · Index
Jul 29, 202610-QIONIS PHARMACEUTICALS, INC. 10-Q 06-30-2026· period Jun 30, 2026Document · Index
Jul 17, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 15, 2026Document · Index
Jul 17, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 15, 2026Document · Index
Jul 17, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 15, 2026Document · Index
Jul 17, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 15, 2026Document · Index
Jul 10, 20268-KRegulation FD disclosure· period Jul 9, 2026Document · Index
Jul 9, 20268-KRegulation FD disclosure; Other events· period Jul 9, 2026Document · Index
Jul 9, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 7, 2026Document · Index
Jul 9, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 7, 2026Document · Index
Jul 9, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 7, 2026Document · Index
Jul 7, 2026144Notice of proposed sale of securitiesDocument · Index
Jul 7, 2026144Notice of proposed sale of securitiesDocument · Index
Jul 7, 2026144Notice of proposed sale of securitiesDocument · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 6, 20264Statement of changes in beneficial ownership (insider trade)· period Jul 1, 2026Document · Index
Jul 1, 2026144Notice of proposed sale of securitiesDocument · Index
Jun 30, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 26, 2026Document · Index
Jun 30, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 26, 2026Document · Index
Jun 30, 20264Statement of changes in beneficial ownership (insider trade)· period Jun 26, 2026Document · Index
Jun 26, 2026144Notice of proposed sale of securitiesDocument · Index

Insider filing activity

104 Form 4 filings appear in IONIS PHARMACEUTICALS INC’s EDGAR record between Oct 28, 2025 and our last refresh. Most are reports by the company’s own directors, officers and 10% owners, but EDGAR also lists a Form 4 under a company when the company itself is the insider — for example, when it owns more than 10% of another public company. Foreign private issuers’ own insiders generally do not file Form 4. A high count is not by itself a signal: many Form 4s report routine stock awards, tax withholding or sales under pre-arranged Rule 10b5-1 plans. Open each filing to see the transaction code, share count and price. What a Form 4 shows.

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Source

  • U.S. Securities and Exchange Commission, EDGAR submissions for CIK 0000874015 and XBRL company facts. IONIS PHARMACEUTICALS INC on EDGAR.
  • Snapshot updated Oct 27, 2026, 11:27 PM EDT. The SEC does not endorse OpenFilings. Company names and tickers are used only to identify the filer; no logos are shown.

Not investment advice. This page summarizes public SEC filings for information only. Figures may contain errors or omissions; confirm everything in the original filing before relying on it.